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KMID : 0387820140210010041
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Clinical Pediatric Hematology-Oncology
2014 Volume.21 No. 1 p.41 ~ p.45
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A Case of Osteosarcoma after Treatment of Endodermal Sinus Tumor
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Jin Da-Hee
Lee Yoon
Lee Jung-Hwa
Lee Kwang-Chul
Kim Chul-Hwan
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Abstract
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Endodermal sinus tumor is a type of germ cell tumor that is relatively common in children. An important problem concerns secondary neoplasms after treatment. We re-port a case of osteosarcoma that developed five years after treatment of intrapelvic endo-dermal sinus tumor. The patient was a seven-year-old girl who presented with right thigh and knee joint pain. The patient had been diagnosed with endodermal sinus tumor five years previously and treated with a regimen consisting of high dose cisplatin, etoposide, bleomycin and surgery but without radiotherapy. We detected a mass shadow on the right distal femur that proved to be osteoblastic osteosarcoma by incisional biopsy. The patient received surgical treatment after chemotherapy that included high dose methotrexate. The follow-up bone scan revealed no abnormal uptakes. There has been no evidence of recurrence eighteen months of follow-up after chemotherapy.
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KEYWORD
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Endodermal sinus tumor, Osteosarcoma, Second primary neoplasm
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